A versatile model of open-fracture infection A CONTAMINATED SEGMENTAL RAT FEMUR DEFECT
نویسندگان
چکیده
Methods Defects were created in the stablised femurs of anaethetised rats, contaminated with Staphylococcus aureus and then debrided and irrigated six hours later. After 14 days, the bone and implants were harvested for separate microbiological analysis. This basic model was developed in several studies by varying the quantity of bacterial inoculation, introducing various doses of systemic antibiotics with and without local antibiotics.
منابع مشابه
A versatile model of open-fracture infection
OBJECTIVES The purpose of this study was to refine an accepted contaminated rat femur defect model to result in an infection rate of approximately 50%. This threshold will allow examination of treatments aimed at reducing infection in open fractures with less risk of type II error. METHODS Defects were created in the stablised femurs of anaethetised rats, contaminated with Staphylococcus aure...
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تاریخ انتشار 2014